Freeze drying and sterilisation Laboratory0 pages

Development of sterilisation cycles
The Laboratory has a specialised autoclave which enables sterilisation of samples by the following methods:

Pure dry steam
sterilisation

•2 – 3 day training courses for maintenance and production staff, with LYOBETA type pilot freeze drying equipment for monitoring
complete processes and creating recipes, plus training on industrial equipment.
•Specific courses on particular topics: programming, qualification, refrigeration, creation of recipes, optimisation of freeze drying cycles,
and; special operations such as: control of the process by resistivity, in-process testing with a moisture control probe, barometric process
control (BTM).

Equipment and systems available in the
Telstar Laboratory
Autoclave Telstar Steridelta A

Air counter-pressure steam
sterilisation

Autoclave Telstar Steridelta W

Specialised training

Water counter-pressure
sterilisation

•Lyoquest model laboratory freeze dryer
•LYOBETA-25 model pilot freeze dryers. Equipped with:
•PLC-based control and SCADA (supervisory control and data acquisition) system
•Isolation valve between chamber and condenser
•Stoppering device
•Measurement of the sublimation front temperature, flow rate and other parameters
by DPE (Dynamic Parameters Estimator)
•Vacuum control by microbleed modulating valve
•Vacuum reading in parallel with Baratron vacuum capacitance manometer and
Pirani gauge
•Moisture sensor in the chamber
•Measurement of the temperature of the product with PT100 probes and
thermocouples
•Sample thief device
•Cryogenic microscope
•System for the rotary freezing of bottles in an alcohol bath
•Resistivity control equipment
•Vial filling equipment
•Final moisture control by the Arizona Instruments Computrac method.
•High frequency system for vacuum control in sealed bottles (non-destructive test)
•Laminar flow cabinet for handling powder products. Preparation of solutions for
freeze drying
•Sterilisation autoclave using pure dry steam, steam-water counter-pressure and
superheated water.

Freeze drying and sterilisation
processes R&D Laboratory

Sterilisation of Client product in the
laboratory’s autoclave
Tests in the autoclave can determine the optimum conditions for
sterilisation for all types of product: solid, porous, liquid, plastic,
and so on.
Product formats which usually require an in-depth study are plastic
containers with liquid inside. The overpressure exerted by the gas
inside the container during sterilisation may permanently deform it
so as to render it unusable.
The external counter-pressure which needs to be exerted throughout the process to prevent deformation of the
container is determined in the laboratory autoclave. This counter-pressure may be exerted with the steam-air mixture
or with superheated water. The choice of which system is most appropriate will depend upon the state in which the
container is to emerge from the autoclave: dry or wet.

Headquarters
Av. Font i Sagué, 55
08227 Terrassa (España)
T +34 937 361 600
F +34 937 861 380

The small volume of the autoclave chamber makes it possible to carry out tests with small quantities of containers.
The results can then be easily transferred to an industrial scale plant.

www.telstar-lifesciences.com
02 309 1111 I
Telstar reserves the right to improvements and specifications changes without notice.