The use of gas mixtures dynamically created in the hemoglobin study0 pages

MCQ Gas Blender 100 Series
High Performance Gas flow Dilutor & Gas flow Mixing System with User Interface
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Introduction
Over the last century, the hemoglobin study has been, and
still is, the keystone in our understanding of human
physiology. The importance of the role of hemoglobin and
the studies undertaken over this molecule have allowed,
starting from the pioneering works of enlightened minds
such as Linus Pauling, Max Perutz and many others until
today worldwide research, the birth and maturation of a new
scientific branch: the molecular medicine. Being a
fundamental component in the complex respiratory system
of all the vertebrates, the hemoglobin has always been a
high interesting scientific subject, widely researched by
using physical, chemical, physiological, and genetic
methods. All these intense efforts allow modern medicine to
have an unparalleled knowledge of hemoglobin molecular
basis, DNA relations, structure-related functions and more
importantly its related diseases and their treatment.
Nevertheless, hemoglobin study constantly proves new and
deeper connections between this molecule and other
complex biological systems that then require new
experimental approaches to be developed.
MCQ Gas Blender 100 Series Application:
The use of gas mixtures dynamically created
in the hemoglobin study
Application Note
Hemoglobin
The Role of Hemoglobin
Hemoglobin is a macromolecule made up of four protein
molecules, the globulin chains called myoglobin, connected
together. The normal adult hemoglobin molecule contains 2
alpha-globulin chains and 2 beta-globulin chains. The dry
content of the red blood cells, the most abundant cells in
vertebrate blood, is composed up to 97% of hemoglobin. Its
main function is to transport oxygen (O2) from the lungs to
tissues (taking role of oxygen binding protein, the
hemoglobin increases the total blood oxygen capacity
seventyfold) and to return carbon dioxide (CO2) from the
tissues to the lungs or gills. Each globulin chain contains an
iron ion embedded in a porphyrin molecule called heme,
which directly binds the oxygen molecule and which is also
responsible for the red color of blood. The heme also
specifically interact with the two other gases, carbon
monoxide (CO) and nitric oxide (NO), both with important
biological roles. The interaction between carbon dioxide and
hemoglobin is instead carried out by the amino-terminal
residues of the protein.
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